CSR

Objectives of the project:

The project aims to develop affordable nanotechnology based therapeutic modality for HNC theranostics. The objectives of the project are:

1. Development and characterization of NIR responsive gold coated lipo-polymeric nanosystems.
2. Incorporation of NIR dye/ chemotherapeutic moieties within the gold coated lipo-polymeric nanosystems.
3. In vitro evaluation of photothermal transduction efficacy, biocompatibility, photothermal mediated cytotoxicity and synergistic effect of combined therapy in cell lines.
4. In vivo biodistribution, toxicity and anti-tumor efficacy of the developed nanosystems in mice tumor model.

Expected outcomes/ deliverables:

1. This strategy may lead to the new affordable theranostic modality for the treatment of HNCs.
2. Liposome gold nanoparticles (Lipos-Au NPs) with a combination of Chemo-PTT/PDT may show additional synergistic effects and can improve therapeutic efficacy.
3. The particle-induced radiation by drug/dye incorporated NIR responsive NPs may be very effective to overcome the drug resistance as well as regrowth and metastasis of the cancer cells.
4. This approach will be valuable for developing a nontoxic and cost-effective treatment for chemoresistance and radio-resistant tumors in patients.

Timeline and Budget:
Year 1: Rs. 9,26,400
Year 2: Rs. 9,86,400
Year 3: Rs. 9,86,400

Proposer Name & Designation:
Dr. Aravind Kumar Rengan, Associate Professor, Department of Biomedical Engineering, IIT- Hyderabad.